doctoral student

The University Hospital Carl Gustav Carus and the Faculty of Medicine together form the Dresden University Medicine. It is committed to excellence in high-performance medicine, medical research and teaching as well as health care for patients throughout the region. Together for the top medicine of tomorrow - you will become part of the University Medicine Dresden.

PhD student at the Institute of Physiological Chemistry

The place must be occupied for 24 months at the 01.06.2025. Remuneration is carried out in accordance with the rules of the collective agreement for the public service of the countries (TV-L).

Needs all your skills - your challenge:

Our working group deals with the process of intramembrane proteolysis, which combines protein degradation with signal transduction and thus represents an important regulatory mechanism for cellular homeostasis. We are currently particularly interested in the SPP/SPPL family of intramembrane proteases, which include the signal peptide peptide (SPP) and various SPP-like homologs. These proteases cleave specific membrane proteins and thus contribute to the homeostasis of the cellular membrane proteins while simultaneously acting as regulatory switches. In recent years, we have extensively investigated the function of these enzymes, both using cell-based approaches and mice as model organisms. Based on this work, we were able to identify roles of SPP/SPPL proteases in the immune system, arteriosclerosis, germ cell development and regulation of glucose metabolism. In the planned PhD project, we would like to further characterize the substrate spectrum and the in vivo function of SPP. The project will therefore combine basic biochemical/cellbiological experimental approaches with the phenotyping of conditional knockout mice, in particular with regard to metabolism and the immune system. The project includes a wide range of experimental techniques. The question combines basic biochemical/cellological questions with the characterization of pathophysiological relevance of biochemical findings and their translational potential.

Further information: https://tu-dresden.de/med/mf/pch/das-institut/arbeitsgruppen/berndschroeder/research Mentrup et al. & Schröder, FEBS J 2024 Mentrup et al. & Schröder, Cell Mol Life Sci 2020 We look forward to your application documents until 04.04.2025

You have a master degree in biochemistry, biology or related subjects You have experimental experiences in one of the following areas: Biochemistry, Cell Biology, Molecular Biology, Immunology You are an excellent team worker* You are happy to examine basic questions in biology and to work scientifically

An exciting promotional project with translational relevance with a diverse range of methods Work in a motivated team in a well-equipped institute attractive remuneration by collective agreement with special payments Use of occupational prevention and fitness services in our health centre Carus Vital incl. Participation in team events, lectures, courses and seminars Care of your children through partnerships with children's institutions near the clinic Precaution for the period after active employment in the form of an occupational pension scheme Use of bike leasing and the possibility of a job ticket Support offers for all areas of life through our family office and employee advice