PhD student -Translational Research Lab - Single cell multi-omics to unravel niche plasticity in AML therapy resistance (m/w/d)

The University Hospital Heidelberg is one of the major healthcare centers in Germany. Our objective is the development of innovative diagnostics and therapies, as well as their quick implementation for the patient. With about 14,000 employees in more than 50 specialized clinical departments with almost 2,500 beds, about 80,000 patients in part-time and full-time inpatient treatment as well as 1,000,000 patients in ambulant treatment are medicated each year. PhD student -Translation resistance Research Lab - Single cell multi-omics to unravel niche plasticity in AML therapy (m/f/d) wanted for 01.10.2025 at the Department of Medicine V, Hematology & Oncology, University Hospital Heidelberg.

For our project “Single cell multi-omics to unravel niche plasticity in AML therapy resistance” we are looking for a PhD student. The project is part of the SFB/CRC 1709 “Cellular Plasticity in Myeloid Malignancies: From Mechanisms to Therapies-. In this CRC we aim to understand how plasticity i.e. non-genetic adaptations of the bone marrow niche induced by the disease or therapeutic agents contribute to drug resistance and relapse. Our ultimate goal is to develop new anti-leukemic therapy.

We are searching for a highly motivated and dedicated student with a strong background in molecular biology and/or cell biology and great enthusiasm for the bone marrow niche and therapy-resistance mechanisms. The PhD student will work in close collaboration with other CRC/SFB members and groups and will perform multiomics single cell sequencing analyses of mouse and human bone marrow cells at leukemia onset, throughout the course of treatment and upon relapse. Ideally, the candidate brings in strong expertise in cell culture and molecular biology techniques. The project thus includes a substantial amount of in vivo work, which will be performed in collaboration with experienced senior researchers. a strong interest and motivation to support experiments is required. The final aim of our studies is to translate the experimental findings into novel treatment strategies for AML patients. Job ID: V000014512 Field of application: Department of Hematology, Oncology and Rheumatology Location: Heidelberg Start date: 01.10.2025 Field of activity: Science and teaching Position type: Part time (65 %) Term: Temporary (2 years with option of extension) Contract: TV-L

Single cell multicomics of bone marrow cells: wet lab experiments involving preparation of cells for transplantation, isolation of cells, treatment with small molecule inhibitors Computational analyses of scSeq data with support of experienced computational researchers Literature research and manuscript writing Imaging of mouse bone marrow Analysis of clinical data and correlation with wet lab findings

Master degree (or similar) in molecular biology, biomedicine, biotechnology, bioinformatics or a related field Experience in molecular biology methods (e.g. PCR, NGS, cell culture) and / or functional cell assays Interest in translational leukemia research and innovative imaging and omics technologies Great interest in pre-clinical in vivo models Ideally initial experience with Bioinformatics experience, especially in R

Goal-oriented, individual training and development opportunities Working with the latest techniques / technical equipment Possibility of doctorate Possibility to publish scientifically Regular team meetings Collectively agreed remuneration, attractive company pension scheme (VBL) 30 days vacation Sustainable travel: job ticket Family-friendly working environment: cooperative arrangements for childcare, grant for child vacation care, advice for employees with relatives in need of care Wide range of health, prevention and sports offers Note: The UKHD is subject to the commissions of the Infection Protection Act. Therefore, a valid measles immunity certificate is required for all persons employed at the UKHD.

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