Post-Doc – Freez-Thaw Studies on Biologics (all genders) (full-time, temporary for 24 months)

Welcome to AbbVie! As part of an international company with 50,000 employees worldwide and around 3,000 employees in Germany, you will have the opportunity of addressing some of tomorrows unmet medical needs in close collaboration with your colleagues. Are you passionate about improving global health care? Do you want to contribute to improve patients' quality of life through your expertise? In a challenging work environment that offers opportunities of developing and increasing your own skills? You've come to the right place! In our Pharmaceutical development department within Product Development Science & Technology (PD S&T) at the Ludwigshafen site, you will be working in a team of talented people and experienced experts towards developing tomorrow's products. In cutting-edge laboratories, you will be setting the highest standards in the competitive field. Moving mountains together – as Post-Doc – Freez-Thaw Studies on Biologics (all genders) (full-time, temporary for 24 months) Product Development, Science and Technology (PDS&T) drives product development of assets which proved effective in early clinical trials and provides support for on-market products. Biologics drug substances are typically stored as frozen solutions prior to drug product manufacturing. The thawing and freezing of these solutions, especially repeated cycles, are known to bear the risk of protein damage. Based on current knowledge of the mechanisms of freeze-thaw instability, you design, conduct and measured studies pushing for a deeper understanding of the dynamic mechanism in relevant formulations and publish results in peer-reviewed journals. A substantial arm of the studies will be evaluations on the influence of excipient crystallization on freeze-thaw instability.

Plan and perform systematic studies to dive deeper into the root causes of freeze-thaw instability of proteins Publish results in peer-reviewed journals and present work at panels and scientific conferences aligned with business objectives Collaborate with international multidisciplinary teams to advance project goals Participate in investigations on the root cause of freeze-thaw instability phenomena of development Demonstrate a high degree of responsibility in maintaining scientific standards and safe laboratory practices Maintain a high level of productivity in the laboratory setting Proactively seek out new information in the literature and increase this into individual project(s) as well as the overall program

Ph.D. in biochemistry or chemistry or related area, preferably with a background in biophysics and crystallography Experience with WAXS/SAXS, thermal analyses and vibrational spectroscopies preferred Work experience in the field of protein aggregation is preventing Experience with analytical methods to detect protein denaturation and aggregation as well as to detect/characterize particles in solution is Affinity to work hand-on with complex analytical equipment and solve related technical problems Business fluent in English, German language skills of advantage Record of scientific initiative and creativity in research or development Capable of independently designing and executing experiments, statistical evaluation, interpreting data, and identifying appropriate follow-up strategies

Here's how we can move mountains together: with a diverse work environment where you can have a real impact with an open corporate culture with an attractive salary with an intense onboarding process with a mentor at your side with flexible work models for a healthy work-life balance with a corporate health management that offers comprehensive health and exercise programs with company social benefits with a wide range of career opportunities in an international organization with top-tier, attractive development opportunities with a strong international network Multiple times, we have been globally recognized as a ''Great Place to Work''' and we are proud to provide our employees with the flexibility to maintain a healthy work-life balance. We take our impact on the environment and our communities seriously and therefore focus on giving something back on a regular basis. We are committed to equality, equity, diversity and (EED&I) – a commitment that is fundamental to us. This includes appreciating different perspectives, creating an inclusive culture and treating all employees with dignity and respect. JOBV1_EN