PhD - Lab on Chip Sample Preparation for Next-Generation Molecular Diagnostics

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Employment type: Limited Working hours: Full-Time Joblocation: Renningen Join our innovative research team. We are looking for a motivated PhD candidate to develop a microfluidic sample-preparation unit operation, based on magnetic beads, enabling next-generation molecular diagnostics (MDx) workflows. Next-generation molecular diagnostics require rugged and automated methods for isolating low-abundance biological - search as pathogens, enzyme tumor DNA (ctDNA), and extracellular vesicles (EVs)-from complex samples. This PhD project aims to develop a scalable, cartridge-compatible platform for the controlled handling of functionalized magnetic particles throughout the complete sample-preparation workflow, including target capture, washing, transfer, resuspension, and release. The central objective is to establish a reusable microfluidic actuation module that interfaces seamlessly with disposable diagnostic cartridges. You will conduct targeted research on the manipulation of magnetic particles and develop multiphysics models (e.g., COMSOL) to optimize particle trajectories and fluid interactions. Furthermore, you will conceptually design and develop a reusable, cartridge-compatible microfluidic handling module that automates the entire target-molecule extraction process (capture, washing, transfer, and release). You will create functional prototypes and experimentally quantify system performance using keymetrics search as target-molecule recovery, processing time, and reproducibility. Last but not least, you will translate your physical understanding and modeling results into rigorous design rules for integration into disposable diagnostics cartridges, delivering transferable models and prototypes for future product development.

Education: excellent master's degree in Biomedical Engineering, Mechanical Engineering, Applied Physics, Microsystems Engineering (MEMS), or a related field Experience and Knowledge: solid knowledge of microfluidics, fluid dynamics, and multiphysics simulation (e.g., COMSOL); practical experience in the design, prototyping, and testing of lab-on-a-chip systems; ideally, familiarity with handling magnetic particles, non-Newtonian fluids (such as blood), or sample preparation for molecular diagnostics (MDx) Personality and Working Practice: you work independently, plan your tasks carefully, and contribute with a high level of commitment and a strong hands-on mentality; you are able to communicate your research findings clearly and bridge the gap between theoretical simulation and physical prototyping, taking ownership of your work Enthusiasm: you are passionate about interdisciplinary scientific work at the intersection of physics, engineering, and biomedicine, approach complex tasks creatively and innovatively, and successfully translate them into practical applications Languages: very good written and spoken German and English

Work-life balance: Flexible working in terms of time, place and working model. Health & Sports: Wide range of health and sports activities. Childcare: Intermediary service for childcare services. Employee discounts: Discounts for employees. Room for creativity: Space for creative work. In-house social counseling and care services: Social counselling and intermediary service for care services.

The recruitment contact or superior will be happy to provide information about the individual benefit plan. .