PhD Candidate (m/f/d) Neurohomeostasis - Department of Psychiatry and Psychotherapy

Branche: Öffentlichkeitsarbeit Branche: Öffentlichkeitsarbeit

The University Hospital Bonn (UKB) is a maximum care hospital with more than 1,300 beds. Our more than 9,000 employees take on tasks in research, teaching and patient care as well as in public health at the highest level. In the science ranking (LOMV) and in the economic result, the UKB is number 1 of the university hospitals in NRW and in 2021 had the third highest case mix index of the university hospitals in Germany.

The following 65% part-time position is to be filled by September 1^st 2025 in the research group Neurohomeostasis, Department of Psychiatry and Psychotherapy of the University Hospital Bonn:

PhD Candidate (m/f/d)

Due to third party funding, the position is limited to 2 years due the project. Additional 2 years will be covered by a partner institution.

Our research focuses on understanding the intricate links between stress, proteostasis, and cellular function, aiming to identify promising therapeutic targets for the treatment of neuropsychiatric disorders. Taking a multidisciplinary and translational approach, we combine cell models, animal experiments, and human studies with protein biochemistry, pharmacology (e.g. autophagy induction, GLP-1 agonists), and advanced multi-omics techniques.

The offered project aims to unravel the interplay between metabolic and psychiatric phenotypes by establishing cellular autophagy as a central mechanism linking bi-directional brain-body interactions in stress-related disorders. Analyses of the autophagic pathway along with plasma proteomics and metabolomic polyamine profiling will be performed from human and murine samples.